Database query

To search for particular genes in the Retinome Database, choose an option from the pull-down lists or enter a desired search term in the corresponding field. To narrow down the selection (e.g. search for genes mapped to chromosome 1 that are specifically expressed in retina/RPE), parameters may be entered in multiple fields. Additionally, the symbol '*' may be used as a wildcard. Once the selection criteria has been entered, press the "Search" button. Activation of the "Reset" button will clear all search fields.




To access all the search criteria, press the "More Options" button:



By default, results are reported in alphabetical order according to the gene symbol in windows containing 20 results each. If desired, the amount of results per page may be increased to 500 using the "Show per page" drop-down option. With the page navigation buttons you can easily jump to the next, previous, first or last page.





To sort results in ascending or descending order for any column, click on top of the column name. An upward or downward arrow will show the current sorting of the selected column. Sorting direction may be reversed by clicking again on the selected column.

Information about the search fields

• Symbols, phenotypes, Gene IDs, chromosomal localization and protein names correspond to those contained in the Entrez Gene database for the corresponding gene. The aliases of a gene will also be queried in the course of a symbol field search.
  
  
• If reliable published information is available, genes are assigned to one or more of the following categories:
  
  
  1. Retinal disease gene: genes implicated in retinal diseases
  2. Retinal localization: genes that have been immunohistochemically proven to be expressed in retina or RPE
  3. Retina or RPE specific: genes which are only expressed in these tissues
  4. Vitamin A/phototransduction: functionally characterized genes known to be involved in Vitamin A metabolism or the phototransduction cascade
  
  
• Selection of a particular study will report all genes reported in the study which had a GeneID as of November 2004
  
  
• The"newer than" field allows to select for genes that have been added in the selected period of time or those where information has been added

Quick Link buttons

With the QuickLinks buttons you can directly access information supplied in other databases and information resources for the corresponding gene very easily.

Clicking on a specific gene symbol will show detailed information for this entry extracted from Entrez Gene. All red lettered entries contain direct links to further resources.

Downloading of results

The "Download results" function enables the user to save the query results locally in three different formats.





In the window that opens up after selecting the option it is possible to select which fields should be downloaded and the format.

Gene Alert service

To receive an E-mail notification when new information about a gene becomes available (e.g. a new paper containing information about the gene is published or new mRNA sequences become available), select the genes of interest in the Retinome Database by clicking first on the corresponding Gene-Alert box/es and then on the "Suscribe to selected" button. You will then be prompted to enter the E-mail address where you want to be notified. In case you want to suscribe to all genes from a particular query, click the “check all� button at the bottom of the page. Repeat this for every page.





In order to unsubscribe from this service or delete a gene, select the Alert Manager option from the main menu found in the left side of the page. After entering your E-mail address you may delete one or more genes as well as your E-mail address from the mailing service.

Citation reference

In order to learn more about the background of RetinaCentral or for citation purposes please refer to the following paper:

Schulz HL, Goetz T, Kaschkoetoe J, Weber BH.
The Retinome - Defining a reference transcriptome of the adult mammalian retina/retinal pigment epithelium. BMC Genomics. 2004 Jul 29. PMID: 15283859

Institute of Human Genetics, University of Wuerzburg © 2005 | Impressum